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KMID : 0616120190500020086
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 2 p.86 ~ p.95
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Anti-inflammatory and Antioxidant Effects of Zizyphus jujuba Miller var. inermis extracts
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Hong Chang-Eui
Chun Young-Hee
Lyu Su-Yun
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Abstract
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In the present study, the effect of Z. jujuba Miller var. inermis Rehder extracts on the secretion of atopic dermatitis (AD)-related cytokines and hyaluronidase activity was investigated. We prepared four fractions, butylene glycol (JB), ethanol (JE), and water (JW), with Z. jujuba Miller var. inermis extracts. JW significantly reduced the secretion of interleukin-8 and JE reduced the secretion of tumor necrosis factor-alpha in human keratinocyte HaCaT cells. Also, hyaluronidase activity was measured by enzyme assay and the fractions inhibited the activity in a dose-dependent manner. In addition, the human dermal fibroblast, HDF-n cells were treated with the extracts and antioxidant activities were measured. The results showed that the extracts increased the free radical scavenging activity and the superoxide dismutase activity. Taken together, Z. jujuba Miller var. inermis extracts reduced the secretion of AD-related cytokines and inhibited the hyaluronidase. In addition, the extracts showed antioxidant activity.
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KEYWORD
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Zizyphus jujuba Miller var. inermis Rehder, Anti-inflammatory, Antioxidant, Atopic dermatitis
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